Home Acta Virologica 2013 Acta Virologica Vol.57, No.4, p.467-470, 2013

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

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Acta Virologica Vol.57, No.4, p.467-470, 2013

Title: Increased formation of autophagosomes in ectromelia virus-infected primary culture of murine bone marrow-derived macrophages
Author: L. MARTYNISZYN, L. SZULC-DĄBROWSKA, A. BORATYŃSKA-JASIŃSKA, M. NIEMIAŁTOWSKI

Abstract: Induction of autophagy by ectromelia virus (ECTV) in primary cultures of bone marrow-derived macrophages (BMDMs) was investigated. The results showed that ECTV infection of BMDMs resulted in increased formation of autophagosomes, increased level of LC3-II protein present in aggregates and extensive cytoplasmic vacuolization. These data indicate an increased autophagic activity in BMDMs during ECTV infection.

Keywords: ectromelia virus; macrophage; autophagy; Atg proteins
Year: 2013, Volume: 67, Issue: 4 Page From: 467, Page To: 470
doi:10.4149/av_2013_04_467


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