Home CONTACT Neoplasma 2014 Neoplasma Vol.61, No.2, p.144-152, 2014

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.61, No.2, p.144-152, 2014

Title: Reduced STMN1 expression induced by RNA interference inhibits the bioactivity of pancreatic cancer cell line Panc-1
Author: J. LI, G. H. HU, F. J. KONG, K. M. WU, B. HE, K. SONG, W. J. SUN

Abstract: Increased expression of STMN1 has been observed in many tumor forms, but its expression and potential biological role in pancreatic cancer is still unknown. In this study, we demonstrated that STMN1 was expressed to a large extent in pancreatic cancer tissues and cell lines as compared to normal pancreatic tissues. Suppression of STMN1 expression via transfection with STMN1-specific siRNA could not only significantly inhibit the proliferation, migration and invasion ability of Panc-1 cells, but also enhance the apoptosis of Panc-1 cells. In addition, downregulation of STMN1 obviously enhanced the acetylation level of α-tubulin. All these results indicated that STMN1 plays an important role in pancreatic cancer development, and might serve as a potential therapeutic target for pancreatic cancer.

Keywords: pancreatic cancer, STMN1, Panc-1, RNA interference (RNAi), cancer therapy
Published online: 02-Dec-2013
Year: 2014, Volume: 61, Issue: 2 Page From: 144, Page To: 152

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