Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Neoplasma Vol.61, No.2, p.205-212, 2014 |
||
Title: Coexpression of IL-6 and TNF-α: prognostic significance on breast cancer outcome | ||
Author: G. TRIPSIANIS, E. PAPADOPOULOU, K. ANAGNOSTOPOULOS, S. BOTAITIS, M. KATOTOMICHELAKIS, K. ROMANIDIS, E. KONTOMANOLIS, I. TENTES, A. KORTSARIS | ||
Abstract: Presented study was conducted to investigate the prognostic significance of the coexpression of serum interleukin-6 (IL-6) and tumor necrosis factor-a (TNF-a) in breast cancer, by correlating their presence with clinicopathological characteristics indicative of tumor progression and the overall survival of breast cancer patients. One hundred twelve consecutive patients with primary breast cancer were prospectively included and evaluated. Serum concentrations of IL-6 and TNF-a were measured by quantitative sandwich enzyme immunoassay (ELISA). Median split was used to subdivide patients with low or high IL-6 and TNF-a levels. A positive association between the expression of the two cytokines was found. The coexpression of high IL-6 and TNF-α was independently associated with extended lymph node (>3) involvement (aOR, 7.8) and lymphovascular invasion (aOR, 14.1), increasing the prognostic significance of each cytokine separately; it also provided additional prognostic information regarding survival, defining a high-risk subgroup of patients with significantly shorter survival and higher risk of death compared to patients with both cytokines low (aHR, 4.45) and patients with only one cytokine high (aHR, 3.63). Our findings suggest that the coexpression of these two cytokines could be used clinically as a useful tumor marker for the extension and the outcome of the disease. |
||
Keywords: IL-6, TNF-α, breast cancer, prognosis, metastasis, survival | ||
Published online: 02-Dec-2013 | ||
Year: 2014, Volume: 61, Issue: 2 | Page From: 205, Page To: 212 | |
doi:10.4149/neo_2014_026 |
||
|
download file |
|