Home CONTACT Neoplasma 2014 Neoplasma Vol.61, No.2, p.218-224, 2014

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ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.61, No.2, p.218-224, 2014

Title: Value of alpha-fetoprotein and clinical characteristics in patients with liver neoplasm
Author: J. B. Xu, F. Z. Qi, G. Xu, G. F. Chen, L. X. Qin, J. H. Zhang


This article aimed to investigate the value of α-fetoprotein (AFP) for the diagnosis of hepatocellular carcinoma (HCC) and to evaluate the relationship between AFP and various clinical variables of HCC comprehensively.
A retrospective study of postoperative patients diagnosed with liver neoplasm from two Chinese centers was enrolled in our study.
A total of 3050 patients were included. The best cut-off point of AFP for the diagnosis of HCC was 20ng/ml with ideal sensitivity (69.74%), specificity (91.18%), LR (4.12) and YI (0.61). Non-HBV infection patients showed the highest specificity (94.44%) but lowest sensitivity (60.13%). In HBV infection.

Patients, HBsAg, HBeAb, and HBcAb positive patients had the highest sensitivity (79.55%) and specificity (58.49%). AFP levels increased significantly in symptomatic patients (p=0.011).

Those patients with tumor sizes ≥10cm had much higher serum AFP level compared with smaller tumors ones (p=0.014). AFP levels increased remarkably in patients with vascular invasion (p=0.015).

Stepwise logistic regression showed tumor size (≥10cm) was an independent predictor of elevated AFP (OR=2.743, 95%CI: 1.167-6.447, P=0.021).

The best discriminating AFP value for the diagnosis of HCC is 20ng/ml; HBsAg, HBeAb and HBcAb positive patients have the optimal sensitivity and specificity; tumor size≥10cm is an independent predictor of elevated AFP.


Keywords: hepatocellular carcinoma, alpha-fetoprotein, diagnosis, hepatitis virus B
Published online: 02-Dec-2013
Year: 2014, Volume: 61, Issue: 2 Page From: 218, Page To: 224

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