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Neoplasma Vol.61, No.2, p.218-224, 2014 |
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Title: Value of alpha-fetoprotein and clinical characteristics in patients with liver neoplasm | ||
Author: J. B. Xu, F. Z. Qi, G. Xu, G. F. Chen, L. X. Qin, J. H. Zhang | ||
Abstract: This article aimed to investigate the value of α-fetoprotein (AFP) for the diagnosis of hepatocellular carcinoma (HCC) and to evaluate the relationship between AFP and various clinical variables of HCC comprehensively. Patients, HBsAg, HBeAb, and HBcAb positive patients had the highest sensitivity (79.55%) and specificity (58.49%). AFP levels increased significantly in symptomatic patients (p=0.011). Those patients with tumor sizes ≥10cm had much higher serum AFP level compared with smaller tumors ones (p=0.014). AFP levels increased remarkably in patients with vascular invasion (p=0.015). Stepwise logistic regression showed tumor size (≥10cm) was an independent predictor of elevated AFP (OR=2.743, 95%CI: 1.167-6.447, P=0.021).
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Keywords: hepatocellular carcinoma, alpha-fetoprotein, diagnosis, hepatitis virus B | ||
Published online: 02-Dec-2013 | ||
Year: 2014, Volume: 61, Issue: 2 | Page From: 218, Page To: 224 | |
doi:10.4149/neo_2014_028 |
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