Home Bratislava Medical Journal 2013 Bratislava Medical Journal Vol.114, No.12, p.675-681, 2013

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.114, No.12, p.675-681, 2013

Title: Biochemical alteration of hepatic functions by histamine H3-receptor agonist and antagonist in immunized rabbits
Author: T. Tripathi, A. A. Khan, M. Shahid, V. Dwivedi, S. Sarkar, M. Siddiqui, H. M. Khan, A. A. Mahdi, R. A. Khan


Aim: The aim of our study was to investigate the functional roles of H3R agonist and antagonist in the development of hepatic functions impairment in immunized rabbits.
Methods: The study comprised of six groups containing 18 rabbits in each. Group-I (negative control) and group-II (positive control) received sterile distilled water intramuscularly while Group III–VI received histamine (100 µgkg-1, s.c.), R-[-]-α-methylhistamine (H3R-agonist, 10 µgkg-1, s.c.), iodophenpropit (H3R-antagonist, 1 µgkg-1, i.m.), and the combination of iodophenpropit (1 µgkg-1, i.m.) plus histamine (100 µgkg-1, s.c.), respectively, b.i.d. (12 hours [8 am and 8 pm]) for 10 days. Groups II–VI were immunized on day 3 with intravenous injection of sheep red blood cells (1×109 cells/ml).

Results: On each experimental day, the mean values of serum enzymes and bilirubin in group-I and group-II showed no changes while in groups III, IV, V, and VI, these enzymes and bilirubin levels showed significant changes (p<0.05), when compared with their values within the group.

Profile of ALT and AST production revealed that ALT and AST levels moderately were changed due to degeneration of the liver.
Conclusion: Our results suggest that R-[-]-α-methylhistamine showed moderate, and histamine and iodophenpropit showed mild degeneration of liver functions; while iodophenpropit plus histamine showed hepatic functions similar to control group. This study suggests that H3R antagonist in combination with histamine may be a non-toxic therapeutic target for histamine research (Fig. 7, Ref. 28).

Keywords: histamine, histamine H3 receptor, agonist, antagonist, R-[-]-α-methylhistamine, iodophenpropit, liver function test.
Year: 2013, Volume: 114, Issue: 12 Page From: 675, Page To: 681

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