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Bratislava Medical Journal Vol.114, No.12, p.675-681, 2013 |
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Title: Biochemical alteration of hepatic functions by histamine H3-receptor agonist and antagonist in immunized rabbits | ||
Author: T. Tripathi, A. A. Khan, M. Shahid, V. Dwivedi, S. Sarkar, M. Siddiqui, H. M. Khan, A. A. Mahdi, R. A. Khan | ||
Abstract: Aim: The aim of our study was to investigate the functional roles of H3R agonist and antagonist in the development of hepatic functions impairment in immunized rabbits. Results: On each experimental day, the mean values of serum enzymes and bilirubin in group-I and group-II showed no changes while in groups III, IV, V, and VI, these enzymes and bilirubin levels showed significant changes (p<0.05), when compared with their values within the group. Profile of ALT and AST production revealed that ALT and AST levels moderately were changed due to degeneration of the liver. |
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Keywords: histamine, histamine H3 receptor, agonist, antagonist, R-[-]-α-methylhistamine, iodophenpropit, liver function test. | ||
Year: 2013, Volume: 114, Issue: 12 | Page From: 675, Page To: 681 | |
doi:10.4149/BLL_2013_144 |
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