Home Bratislava Medical Journal 2013 Bratislava Medical Journal Vol.114, No.12, p.682-688, 2013

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.114, No.12, p.682-688, 2013

Title: The effects of L-carnitine and N-acetylcysteine on carbontetrachloride induced acute liver damage in rats
Author: A. Cetinkaya, B. Kantarceken, E. Bulbuloglu, E. B. Kurutas, H. Ciralik, Y. Atli

Abstract: Aim: To investigate the effects of L-carnitine (LCAR) and N-acetylcysteine (NAC) on carbon tetrachloride (CCl4)-induced acute liver damage in rats.
Material and methods: Totally, 40 rats in 5 groups were included in the study. The first group was the control group. Group 2 received CCl4 (2 ml/kg). Group 3 was given CCl4 + NAC (150 mg/kg). The rats in the Group 4 were administered CCl4 + LCAR (100 mg/kg), and the rats in the Group 5 were given CCl4 + NAC + LCAR. Both CCl4 and the treatment protocols were administered via intraperitoneal route for 10 days. Tissue oxidative stress and antioxidant markers were investigated in liver tissue and serum liver enzymes were measured.
Results: The levels of blood liver enzymes (ALT and AST) increased significantly in the Group 2. However, they decreased markedly in all treatment groups. While malondialdehyde and myeloperoxidase levels in the liver tissue samples increased significantly in the 2nd group, those levels were determined to be decreased significantly in all treatment groups. When the liver tissue antioxidant levels were evaluated; reduced glutathione and catalase decreased markedly in the 2nd group, but increased following the administration of NAC and LCAR. The activities of liver tissue superoxide dismutase did not differ significantly among the groups. In the histopathologic evaluation of liver tissues, on the other hand, diffuse hepatosteatosis was observed in all groups except the control group and there was no significant difference among the groups from the point of steatosis.
Conclusion: LCAR and NAC were concluded to have beneficial effects on the acute liver damage induced by CCl4 administration (Tab. 1, Fig. 5, Ref. 52).

Keywords: carbontetrachloride, oxidative stress, liver damage, l-carnitine, n-acetylcysteine.
Year: 2013, Volume: 114, Issue: 12 Page From: 682, Page To: 688
doi:10.4149/BLL_2013_145


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