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Bratislava Medical Journal Vol.114, No.12, p.708-710, 2013 |
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Title: Glycogen phosphorylase BB as a potential marker of cardiac toxicity in patients treated with anthracyclines for acute leukemia | ||
Author: J. M. Horacek, L. Jebavy, M. Vasatova, R. Pudil, M. Tichy, M. Jakl, J. Maly | ||
Abstract: Objectives: The aim of the presented study was to assess plasma glycogen phosphorylase BB (GPBB) concentrations in acute leukemia patients treated with anthracycline containing chemotherapy. Results: Before chemotherapy, the mean plasma GPBB concentration was 5.25±3.81 µg/L, increased above the cut-off in 1 patient (4.2 %). After the first chemotherapy, the mean GPBB was 6.61±5.54 µg/L, positive in 7 (29.2 %) patients. Six months after treatment, the mean GPBB was 10.06±11.41 µg/L, positive in 8 (33.3 %) patients. Six months after treatment, we found a significant correlation between elevation in GPBB and diastolic left ventricular dysfunction on echocardiography (r=0.621; p<0.0001). The differences in plasma GPBB between healthy blood donors and patients treated for acute leukemia were statistically significant (p<0.01 in all cases).
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Keywords: glycogen phosphorylase BB, cardiac toxicity, chemotherapy, anthracyclines, acute leukemia. | ||
Year: 2013, Volume: 114, Issue: 12 | Page From: 708, Page To: 710 | |
doi:10.4149/BLL_2013_149 |
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