Home CONTACT Neoplasma 2014 Neoplasma Vol.61, No.3, p.331-339, 2014

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.61, No.3, p.331-339, 2014

Title: The biological markers and results of treatment in male breast cancer patients. The Cracow experience.
Author: B. SAS-KORCZYNSKA, J. NIEMIEC, A. HARAZIN-LECHOWSKA, S. KORZENIOWSKI, D. MARTYNOW, A. ADAMCZYK, A. SOKOLOWSKI

Abstract:

Male breast cancer is a rare form of carcinoma with an incidence rate of approximately 0.5-1% compared with cases of breast carcinoma as a whole. Male breast cancer reacts effectively to endocrine therapy because of a high frequency of hormone receptor expression.
The aim of the present study was the assessment of correlations between stage, grade, expression of steroid receptors, basal/mesenchymal markers and proliferation index, as well as analysis of the impact of the above-mentioned parameters on overall (OS) and disease-free survival (DFS) in the group of 32 male breast cancer patients, treated at the Centre of Oncology in Cracow.

We showed the significant positive correlation between MIB-1 LI and tumor stage, and hormone receptors (ER or PgR) immunonegativity, and expression of EGFR, vimentin (p<0.05) and P-cadherin (the last at statistical border).

The presence of any of basal or masenchymal markers correlated with a more advanced tumor stage. Moreover tumors without vimentin expression were characterised by lower MIB-1 LI and were more frequently EGFR immunonegative.

We found that hormone receptor negativity, vimentin immunopositivity and high MIB-1 LI are significant independent indicators of poor OS and DFS for male breast cancer patients (p<0.05).



Keywords: male breast cancer, basal markers, mesenchymal markers, nodal status, hormonal receptors
Published online: 20-Mar-2014
Year: 2014, Volume: 61, Issue: 3 Page From: 331, Page To: 339
doi:10.4149/neo_2014_043


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