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Neoplasma Vol.61, No.3, p.331-339, 2014 |
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Title: The biological markers and results of treatment in male breast cancer patients. The Cracow experience. | ||
Author: B. SAS-KORCZYNSKA, J. NIEMIEC, A. HARAZIN-LECHOWSKA, S. KORZENIOWSKI, D. MARTYNOW, A. ADAMCZYK, A. SOKOLOWSKI | ||
Abstract: Male breast cancer is a rare form of carcinoma with an incidence rate of approximately 0.5-1% compared with cases of breast carcinoma as a whole. Male breast cancer reacts effectively to endocrine therapy because of a high frequency of hormone receptor expression. We showed the significant positive correlation between MIB-1 LI and tumor stage, and hormone receptors (ER or PgR) immunonegativity, and expression of EGFR, vimentin (p<0.05) and P-cadherin (the last at statistical border). The presence of any of basal or masenchymal markers correlated with a more advanced tumor stage. Moreover tumors without vimentin expression were characterised by lower MIB-1 LI and were more frequently EGFR immunonegative. We found that hormone receptor negativity, vimentin immunopositivity and high MIB-1 LI are significant independent indicators of poor OS and DFS for male breast cancer patients (p<0.05). |
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Keywords: male breast cancer, basal markers, mesenchymal markers, nodal status, hormonal receptors | ||
Published online: 20-Mar-2014 | ||
Year: 2014, Volume: 61, Issue: 3 | Page From: 331, Page To: 339 | |
doi:10.4149/neo_2014_043 |
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