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Neoplasma Vol.61, No.3, p.340-351, 2014 |
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Title: Update meta-analysis on 1790G/A polymorphism and cancer risk: Evidence from 26 studies | ||
Author: P. LIU, H. SHI, Y. YANG, R. LIU, C. HUANG, H. SHU, J. LI, Q. CHEN, Y. YANG, M. CAI | ||
Abstract: The results from the published studies on the association between hypoxia-inducible factor-1(Hif-1/HIF-1) polymorphisms and cancer risk are conflicting. The common 1790G/A rs11549467) genetic polymorphism has been reported to be functional and may contribute to genetic susceptibility to cancers. However, the association between 1790G/A (rs11549467) and cancer risk remains inconclusive. We also observed that the AA genotype might modulate lung cancer (OR=5.42[2.75-10.70]), pancreatic cancer (OR=9.30[1.12-77.61]) and oral squamous cell carcinoma (OSCC) (OR=13.32[1.57-112.75]) risk comparing with the GG genotype. Moreover, a significantly increased cancer risk was found in homozygote comparison (AA vs. GG) and recessive genetic model (AA vs. AG/GG) among Caucasian population. When stratified by study design, significantly elevated susceptibility to cancer was found among hospital-based studies. |
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Keywords: Hif-1/HIF-1, 1790G/A, cancer, genetic polymorphism, meta-analysis | ||
Published online: 31-Jan-2014 | ||
Year: 2014, Volume: 61, Issue: 3 | Page From: 340, Page To: 351 | |
doi:10.4149/neo_2014_044 |
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