Home HOME Endocrine Regulations 2014 Endocrine Regulations Vol.48, No.1, p.3-8, 2014

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Founded: 1967
ISSN 1210-0668
E-ISSN 1336-0329

Published in English

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Endocrine Regulations Vol.48, No.1, p.3-8, 2014

Title: Effect of ghrelin on renal erythropoietin production in chronic hypoxic rats
Author: H. Feizi, K. Rajaee, R. Keyhanmanesh, M. R. Aliparasti, S. Almasi, M. R. Alipour
Abstract: Objective. Ghrelin, a 28 amino acid peptide, has diverse effects in body organs. Erythropoietin is a key mediator in increasing the red blood cells during hypoxia. Previously, we have shown that ghrelin has a polycythemic effect. In the present study, we evaluated the effect of ghrelin on erythropoietin gene expression with the aim to find out the mechanism of its effect.
Methods. Thirty two adult male Wistar rats were divided randomly into four groups. The hypoxic condition was induced by placing the rats into the hypoxic chamber with 11% oxygen for two weeks. Saline- and ghrelin-treated control rats remained in room with a regular air conditions. Erythropoietin gene expression was measured by real-time reverse transcription-polymerase chain reaction (RT-PCR). Plasma erythropoietin was measured by enzyme linked immunosorbent assay (ELISA).
Results. After 2-weeks of hypoxia, erythropoietin transcripts and erythropoietin plasma levels were significantly increased in hypoxic animals compared with control animals. Ghrelin treatment decreased both plasma erythropoietin and erythropoietin gene expression only in the hypoxic rats.
Conclusions. Our data indicate that ghrelin might induce polycythemia through an erythropoietin-independent manner. However, to confirm this hypothesis and to find out the precise mechanism of this phenomenon further investigations are needed.
Keywords: ghrelin, kidney, erythropoietin, chronic hypoxia
Year: 2014, Volume: 48, Issue: 1 Page From: 3, Page To: 8
doi:10.4149/endo_2014_01_3
Price: 12.00 €





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