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Bratislava Medical Journal Vol.115, No.3, p.121-124, 2014 |
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Title: Assessing the toxic effects of hydroalcoholic extract of Stachys lavandulifolia Vahl on rat’s liver | ||
Author: A. Taghikhani, H. Afrough, R. Ansari-Samani, N. Shahinfard, M. Rafieian-Kopaei | ||
Abstract: Aims: Stachys lavandulifolia Vahl is a frequently used plant to treat different diseases, but its probable toxic effects have not been reported yet. This study aimed to study the toxicity of the extract on rats’ liver. Results: In the first month, the increase of ALP at all doses and the increase of AST at 200 mg/kg was significant, compared to the control group (p<0.05). In the second month, AST increased at the dosage of 150mg/kg, and ALP decreased at the dosage of 100 mg/kg, compared to the control group (p<0.05). Histopathological assessment showed a significant dose dependent increase both in necrotic-inflammatory reactions and fibrotic lesions, in the first and second months, compared to the control group (p<0.001). |
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Keywords: animal, drug toxicity, toxicity, herb. | ||
Year: 2014, Volume: 115, Issue: 3 | Page From: 121, Page To: 124 | |
doi:10.4149/BLL_2014_026 |
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