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Neoplasma Vol.61, No.4, p.433-438, 2014 |
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Title: Prognostic factors influencing survival in 35 patients with malignant peritoneal mesothelioma | ||
Author: H. KAYA, C. SEZGİ, A. C. TANRİKULU, M. TAYLAN, O. ABAKAY, H. S. SEN, A. ABAKAY, M. KUCUKONER, M. KAPAN | ||
Abstract: Malignant mesothelioma is a rare but highly lethal form of cancer that affects the serosal membranes. Malignant peritoneal mesothelioma (MPM) is the second most common form of malignant mesothelioma (pleural mesothelioma is the most common). The aim of this study was to evaluate prognostic factors influencing the survival of patients with MPM. The mean age of the 35 patients was 59.0±14.4 years, the mean survival time was 16.2±12.9 months, and the majority of the histopathological types of MPM were epithelial (68.6%). 82.9% of the patients had been exposed to asbestos, and the mean duration of exposure was 28.3±14.5 years. The most frequent symptoms were abdominal distention/pain, weight loss, dyspnea, and chest pain. The mean interval between the onset of symptoms and the diagnosis was 4.6±3.3 months. Platinum-based combination chemotherapy in combination with supportive care was used in the treatment of 68.6% of the patients, while supportive treatment alone was used in the others. Our results revealed that patients who were >60 years old (p=0.019), who were exposed to asbestos >20 years (p=0.033), who had an ECOG PS of 3 (p=0.000) were more likely to have a poor MPM prognosis.
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Keywords: Malignant peritoneal mesothelioma, prognostic factors, survival | ||
Published online: 17-Mar-2014 | ||
Year: 2014, Volume: 61, Issue: 4 | Page From: 433, Page To: 438 | |
doi:10.4149/neo_2014_053 |
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