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Neoplasma Vol.61, No.4, p.453-460, 2014 |
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Title: Upregulation of microRNA-17-92 cluster associates with tumor progression and prognosis in osteosarcoma | ||
Author: X. LI, H. YANG, Q. TIAN, Y. LIU, Y. WENG | ||
Abstract: MicroRNA-17-92 (miR-17-92) cluster has been demonstrated to play a crucial role in various human cancers. However, its effects in osteosarcoma have not yet been elucidated. The purpose of this study was to investigate the clinical significance of miR-17-92 cluster in osteosarcoma. The relative expression of miR-17-92 cluster in osteosarcoma tissues was significantly higher than those in adjacent normal tissues (P=0.001). And there was a relationship between miR-17-92 cluster upregulation and advanced TNM stage of osteosarcoma patients (P=0.037). Moreover, higher miR-17-92 cluster expression clearly predicted poorer Recurrence-free survival (P<0.001) and Overall survival (P=0.002). In the multivariate analysis, high miR-17-92 cluster expression was an independent prognostic factor for Recurrence-free survival (P<0.001) and Overall survival (P=0.002). Furthermore, the cellular proliferation, invasion, and migration of osteosarcoma cell lines were significantly accelerated by miR-17-92 cluster plasmid in vitro assays. |
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Keywords: MiR-17-92 cluster, osteosarcoma, recurrence-free survival, overall survival, tumor progression, prognosis | ||
Published online: 20-Mar-2014 | ||
Year: 2014, Volume: 61, Issue: 4 | Page From: 453, Page To: 460 | |
doi:10.4149/neo_2014_056 |
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