Home CONTACT Neoplasma 2014 Neoplasma Vol.61, No.4, p.468-475, 2014

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6 times a year.
Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.61, No.4, p.468-475, 2014

Title: Decreased expression of ING2 gene and its clinicopathological significance in Chinese NSCLC patients
Author: Y. Q. PAN, X. ZHANG, D. P. XU, W. G. BAO, A. F. LIN, H. H. XU, W. H. YAN

Abstract: The inhibitor of growth 2 (ING2) is a member of ING family, involved in cell cycle regulation, DNA repair, apoptosis and senescence, and participating in chromatin remodeling and transcriptional regulation by histone modification. Recent researches suggest ING2 plays roles in carcinogenesis both as tumor suppressor gene and ongocene depending on tumor types and cell status. Here, we investigated the status of ING2 in a series of 64 Chinese non-small cell lung cancer (NSCLC) patients using immunohistochemistry (IHC) and confirmed the results with Western blotting. RT-PCR results revealed the expression level of ING2 was consistent with mRNA level. The IHC results showed that ING2 protein expression was significantly decreased in NSCLC samples compared with normal lung tissues (P

Keywords: inhibitor of growth 2, non-small cell lung cancer, pathology
Published online: 09-Apr-2014
Year: 2014, Volume: 61, Issue: 4 Page From: 468, Page To: 475

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