Home Acta Virologica 2014 Acta Virologica Vol.58, No.1, p.20-27, 2014

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Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

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Acta Virologica Vol.58, No.1, p.20-27, 2014

Title: Growth characteristics and cytokine/chemokine induction profiles of dengue viruses in various cell lines
Author: B. YOHAN, R. INDAH KENDARSARI, K. MUTIA, A. BOWOLAKSONO, A. R. HARAHAP, R. TEDJO SASMONO

Abstract: The dengue disease varies clinically from mild fever to hemorrhagic fever up to potentially fatal shock syndrome. Such differences in manifestation of dengue virus (DENV) infection have been ascribed to intrinsic differences in DENVs. Four DENV serotypes or four dengue viruses (DENV-1 to DENV-4) have been clearly distinguished; however, only limited information is available on their biological characteristics in vitro. To shed more light on this subject, replication kinetics of all four DENVs in various cell lines and induction of 26 cytokines/chemokines were investigated. The results showed that, (i) all DENVs replicated relatively similarly in various cell lines, (ii) DENV-1 was most effective in this regard, (iii) A549 cells showed the highest virus replication rate compared to other cells, and (iv) all DENVs induced in A549 cells similar levels of several cytokines/chemokines, namely eotaxin, granulocyte colony stimulating factor (G-CSF), interferon alpha 2 (IFN-α2), interleukins 6, 8 15 (IL-6, IL-8, IL-15), and IP-10. In conclusion, this study revealed a similarity in growth characteristics and cytokine/chemokine induction profile for all four DENV serotypes in vitro.

Keywords: dengue viruses; cell lines; growth characteristics; cytokines; chemokines
Year: 2014, Volume: 58, Issue: 1 Page From: 20, Page To: 27
doi:10.4149/av_2014_01_20


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