Home Acta Virologica 2014 Acta Virologica Vol.58, No.1, p.28-33, 2014

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Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

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Acta Virologica Vol.58, No.1, p.28-33, 2014

Title: IL-18 promoter -137G/C polymorphism correlates with chronic hepatitis B and affects the expression of interleukins
Author: H. JIANG, H. CAO, G. LIU, Q. HUANG, Y. LI

Abstract: The relationship between the interleukin (IL)-18 promoter -137G/C polymorphism and plasma levels of IL-18, IL-12, IL-4, and IFN-γ in chronic hepatitis B (CHB) patients and healthy subjects was investigated. The polymorphism was genotyped by a ligase detection reaction-PCR (LDR-PCR), while the cytokines were assayed by ELISA. Compared with healthy subjects, CHB patients exhibited an increased frequency of the G allele, GG genotype and increased IL-4 levels, but decreased levels of IL-18, IL-12, and IFN-γ. A positive correlation for IL-18 ~ IL-12 ~ IFN-γ and a negative correlation for IL-18 ~ IL-4 were found. We conclude that the IL-18 promoter -137G polymorphisms correlated with CHB infection and influenced the expression of IL-18. The studied interleukins represent an immunomodulatory network that plays important roles in host immune responses to CHB infection.

Keywords: chronic hepatitis B; polymorphism; interleukins; interferon gamma; cytokines
Year: 2014, Volume: 58, Issue: 1 Page From: 28, Page To: 33
doi:10.4149/av_2014_01_28


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