Home Acta Virologica 2014 Acta Virologica Vol.58, No.1, p.76-83, 2014

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.58, No.1, p.76-83, 2014

Title: The effect of Astragalus polysaccharide on the Epstein-Barr virus lytic cycle
Author: Q. GUO, X. SUN, Z. ZHANG, L. ZHANG, G. YAO, F. LI, X. YANG , L. SONG, G. JIANG

Abstract: Effects of a polysacharide from Chinese herbal plant Astragalus membranaceus (APS) on the expression of Epstein-Barr virus (EBV) immediate early proteins Zta, Rta and EA-D in Raji cells were examined. EBV switch from latent to lytic cycle in Raji cells was induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and sorbol butyrate (SB) and the effects of APS were examined by immunofluorescence, western blotting and flow cytometry. APS in a non-cytotoxic concentration of 30 μg/ml significantly suppressed the expression of Zta, Rta and EA-D during the EBV lytic cycle. Our observations indicate that APS is potentially useful as an anti-EBV drug.

Keywords: Astragalus polysaccharide; Epstein-Barr virus; anti-EBV drug
Year: 2014, Volume: 58, Issue: 1 Page From: 76, Page To: 83
doi:10.4149/av_2014_01_76


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