Home Acta Virologica 2014 Acta Virologica Vol.58, No.1, p.86-91, 2014

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ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.58, No.1, p.86-91, 2014

Title: The characteristics of synonymous codon usage in the initial and terminal translation regions of encephalomyocarditis virus
Author: X.-X. MA, Y.-P. FENG, J.-L. LIU, Y.-Q. ZHAO, L. CHEN, P.-H. GUO, J.-Z. GUO, Z.-R. MA

Abstract: The synonymous codon usage patterns in the initial and terminal translation regions (ITR, TTR) of the whole coding sequence of encephalomyocarditis virus (EMCV) were analyzed in relation to those in its natural hosts using the sequences accessible in databases. In general, some low-usage host codons were found over-represented in the ITR and TTR of the virus, while some high-usage host codons were found under-represented in the two viral regions. These relationships are thought to participate in the regulation of the speed of translation of viral proteins and in the suppression of ribosomal traffic jams, both aiming at the increase of virus yields.

Keywords: encephalomyocarditis virus; initial translation region; terminal translation region; synonymous codon usage
Published online: 10-Apr-2014
Year: 2014, Volume: 58, Issue: 1 Page From: 86, Page To: 91
doi:10.4149/av_2014_01_86


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