Home HOME General Physiology and Biophysics 2014 General Physiology and Biophysics Vol.33, No.2, p.157–168, 2014

Journal info


Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

Aims and Scope
Editorial Info
Abstracting and Indexing
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

General Physiology and Biophysics Vol.33, No.2, p.157–168, 2014

Title: Long-term effects of somatostatin 14 on the pituitary-ovarian axis in rats
Author: Nataša M. Nestorović, Milica N. Manojlović-Stojanoski, Svetlana L. Trifunović, Nataša M. Ristić, Branko R. Filipović, Branka T. Šošić-Jurjević, Verica Lj. Milošević
Abstract: The long-term effects of somatostatin 14 (SST-14) on the pituitary-ovarian axis were examined. Female Wistar rats received 20 µg/100 g b.w. doses subcutaneously twice daily for 5 consecutive days in the infantile (from 11th to 15th day) or peripubertal (from 33rd to 37th day) period of life. Females treated as infants were killed in the peripubertal (38th day) or adult period of life (80th day), and those treated during peripuberty as adults (80th day). Pituitary follicle-stimulating (FSH), luteinizing (LH) and somatotropic (GH) cells, and ovaries were analyzed by stereology and morphometry. Serum FSH and LH concentrations were determined by RIA. FSH and LH cell volumes were significantly decreased in pituitaries of peripubertal females treated with SST-14 as infants, and in adult females treated during peripuberty. GH cell volume was decreased in all treated rats. In the ovaries, enlargement of the non-growing pool of follicles was detected in adult females treated during peripuberty. SST-14 applied to infant rats did not lead to changes in initial follicular recruitment, but it disturbed follicle growth and development at later stages. It can be concluded that SST-14 exerted long-term inhibitory effects on the pituitary-ovarian axis and GH cells in rats.
Keywords: Gonadotropic cells — Somatotropic cells — Ovary — Folliculogenesis — Stereology
Year: 2014, Volume: 33, Issue: 2 Page From: 157, Page To: 168
doi:10.4149/gpb_2014001


download file


© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.