Home Bratislava Medical Journal 2014 Bratislava Medical Journal Vol.115, No.5, p.256-259, 2014

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.115, No.5, p.256-259, 2014

Title: The effect of dexketoprofen on ischemia reperfusion injury
Author: Y. Yildirim, D. Karakaya, E. Kelsaka, A. Aksoy, M. Y. Gülbahar , A. Bedir

Abstract:

Objective: The purpose of this study was to demonstrate the effects of dexketoprofen on experimental ischemia/reperfusion injury induced in rat testicles.
Methods: Twenty-four male Wistar albino-type rats were randomly separated into three groups. To develop testicular torsion, the right testicle was rotated 720° clockwise. After five hours of rotation, reperfusion was applied for 24 hours. The control group rats (Group C) had no procedures or treatments; basal numbers were used. Intraperitoneal 25 mg/kg dexketoprofen (1 cc) (Group D) or the same volume of serum physiologic (Group SP) were given to the Group D and Group SP rats 40 minutes before and 12 hours after detorsion. Twenty-four hours after detorsion, histopathological evaluation was performed by bilateral orchiectomy. Malondialdehyde (MDA) levels were detected in testicular tissue and in serum.


Results: Histopathologic changes in the spermatic cells of torsioned testicles in Group D were significantly less than those of Group SP (p < 0.05).

MDA levels in both testicles in Group D were similar to those of the control group. Although they were lower than Group SP, the difference was not statistically significant.

Serum MDA levels were lower in Group D compared to the other groups (p < 0.05).


Conclusion: We detected that dexketoprofen decreases I/R injury in both the torsion-formed testicle and the contralateral testicle. Thus, in patients who have urgent surgery for testicular detorsion, dexketoprofen can be preferred as an analgesic to reduce I/R injury. Further study is warranted to demonstrate this effect of dexketoprofen (Tab. 3, Fig. 1, Ref. 30).



Keywords: testicle, ischemia-reperfusion injury, dexketoprofen.
Year: 2014, Volume: 115, Issue: 5 Page From: 256, Page To: 259
doi:10.4149/BLL_2014_053


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