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Bratislava Medical Journal Vol.115, No.5, p.267-271, 2014 |
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Title: Effect of sildenafil citrate on secondary healing in full thickness skin defects in experiment | ||
Author: E. Cakmak, A. Karasoy Yesilada, K. Z. Sevim, O. Sumer, H. S. Tatlidede, D. Sakiz | ||
Abstract: Objectives: An acceleration of the wound healing process expedites chronic wound patient’s return to normal social environments significantly. Sildenafil, a cyclic guanosine monophosphate (cGMP)-dependent phosphodiesterase- 5 inhibitor has been shown to be a potent stimulator of angiogenesis through upregulation of cGMP. In our study, sildenafil was administered orally as a cost-effective supplement in the treatment of full thickness defects and chronic wounds in that manner with low incidence of side effects and morbidity. Control group (n =36) was divided further into a secondary healing group consisting of 9 rats and a pathology group consisting of 27 rats (pathology group 1: 9 rats, 4th and 7th day of wound healing, pathology group 2: 9 rats, 10th and 14th day of wound healing, pathology group 3: 9 rats, 21st and 28th day of wound healing. |
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Keywords: sildenafil citrate, secondary wound healing. | ||
Year: 2014, Volume: 115, Issue: 5 | Page From: 267, Page To: 271 | |
doi:10.4149/BLL_2014_055 |
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