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Endocrine Regulations Vol.48, No.2, p.103-108, 2014 |
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Title: MicroRNA-146a expression and its intervention in NF-кB signaling pathway in diabetic rat aorta | ||
Author: S. S. Emadi, F. G. Soufi, A. M. Khamaneh, M. R. Alipour | ||
Abstract: Objective. The present study was designed to evaluate whether microRNA-146a, as an NF-кB regulating factor and its adapter proteins (TRAF6 and IRAK1), are affected by diabetes in rat aorta. Male Wistar rats were randomly divided into control and diabetic groups (n=6 in each). Diabetes was induced by a single injection of streptozotocin (55 mg/kg; i.p.) in 12 h fasted rats. The gene expression of microRNA-146a, NF-κB, IRAK1, and TRAF6 were determined by real time PCR. The expression of microRNA-146a was down-regulated in diabetic aorta when compared with the control group (p<0.05). The mRNA expression levels of NF-кB, TRAF6 and IRAK1 also increased in the diabetic rat aorta when compared with their control counterparts (p<0.01 for all comparisons).
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Keywords: diabetes, aorta, microRNA-146a, NF-κB, IRAK1, TRAF6 | ||
Year: 2014, Volume: 48, Issue: 2 | Page From: 103, Page To: 108 | |
doi:10.4149/endo_2014_02_103 |
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