Home HOME Acta Virologica 2014 Acta Virologica Vol.58, No.2, p.103-107, 2014

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

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Acta Virologica Vol.58, No.2, p.103-107, 2014

Title: Characteristics and functions of human cytomegalovirus UL128 gene/protein
Author: R. TAO, J. XU, H. H. GAO, W. T. ZHAO, S. Q. SHANG

Abstract: Human cytomegalovirus (HCMV) ORF UL128 protein is highly conserved among viral field isolates and functions in two different molecular forms, monomeric UL128 protein and in a complex with glycoproteins gH, gL, UL130, and UL131A protein. Monomeric UL128 protein works as soluble chemokine analogue to attract peripheral blood mononuclear cells (PBMCs) and selectively induces expression of interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) in PBMCs. The gH/gL/UL128/UL130/UL131A complex is indispensable for entry into both endothelial and epithelial cells. In conclusion, UL128 plays an important role in HCMV infection.

Keywords: human cytomegalovirus; UL128 gene/protein; chemokine
Year: 2014, Volume: 58, Issue: 2 Page From: 103, Page To: 107

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