Home Acta Virologica 2014 Acta Virologica Vol.58, No.2 p.114-119, 2014

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.58, No.2 p.114-119, 2014

Title: Peripheral blood mononuclear cells from field cattle immune to bovine viral diarrhea virus (BVDV) are permissive in vitro to BVDV
Author: V. GUPTA, N. MISHRA, A. PATERIYA, S. P. BEHERA, K. RAJUKUMAR

Abstract: The aim of this study was to determine the in vitro permissivity of peripheral blood mononuclear cells (PBMCs) from bovine viral diarrhea virus (BVDV)-immune field cattle to homologous and heterologous BVDVs. PBMCs from seventeen BVDV-naïve and sixteen BVDV-immune animals were infected with noncytopathic BVDV-1 or BVDV-2. The immune status of cattle was indicated by the presence of virus neutralizing antibodies, while viral load of PBMCs was determined by real-time RT-PCR. The results revealed that the PBMCs from naïve or immune animals were permissive to either BVDV-1 or BVDV-2, but the viral load was significantly higher for the naïve than for the immune animals. Furthermore, the load of homologous virus in PBMCs from immune animals was lower than that of heterologous virus. Our results provide evidence that the PBMCs from BVDV-immune cattle in field are susceptible to reinfection with homologous or heterologous BVDV, albeit to a lower extent in the former case.

Keywords: bovine viral diarrhea virus; peripheral blood mononuclear cells; cattle; immunity; virus permissivity in vitro
Year: 2014, Volume: 58, Issue: 2 Page From: 114, Page To: 119
doi:10.4149/av_2014_02_114


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