Acta Virologica Vol.58, No.2 p.120-127, 2014

Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

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Acta Virologica Vol.58, No.2 p.120-127, 2014
Title: Alterations in microRNA expression profile in rabies virus-infected mouse neurons
Author: N. Shi, X. Y. Zhang, C.Y. Dong, J. L. Hou, M. L. Zhang, Z. H. Guan, Z. Y. lI, M. Duan

Abstract: Rabies virus (RABV) is known to cause a fatal infection in many mammalian species, yet its pathogenesis remains poorly understood. This study was performed to analyze the microRNA (miRNA) expression profiles in RABV-infected primary neurons of mice. A total of 53 miRNAs were found to be differentially expressed in RABV-infected samples compared with mock samples in a time-dependent manner. Among them, the expression of ten miRNAs was validated by real-time RT-PCR. Potential target genes of differentially expressed miRNAs were predicted by TargetScan. Further bioinformatics analysis indicated that these predicted targets were overrepresented in neuronal function-related Gene Ontology (GO) terms and biological pathways. The results of this study suggest that RABV may cause neuronal dysfunction by regulating cellular miRNA expression.

Keywords: rabies virus; microRNA; expression; microarray; neurons; mouse

Year: 2014, Volume: 58, Issue: 2	Page From: 120, Page To: 127
doi:10.4149/av_2014_02_120
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