Home Bratislava Medical Journal 2014 Bratislava Medical Journal Vol.115, No.6, p.367-371, 2014

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.5

 

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Bratislava Medical Journal Vol.115, No.6, p.367-371, 2014

Title: Effects of aqueous soybean, mistletoe and red clover extracts on activities of adenosine deaminase and xanthine oxidase enzyme
Author: M. Namuslu, H. Kocaoglu, H. T. Celik, A. Avci, E. Devrim, Y. Genc, E. Gocmen, I. B. Erguder, I. Durak
Abstract: Soybean (Glycine max), mistletoe (Viscum album) and red clover (Trifolium pratence) have been argued to have anti-cancer effects. In the present study it was aimed to investigate possible effects of these plant extracts on the activities of DNA turn-over enzymes, namely adenosine deaminase (ADA) and xanthine oxidase (XO) in cancerous and non-cancerous gastric and colon tissues. For this aim, 6 cancerous and 6 non-cancerous adjacent human gastric tissues, and 7 cancerous and 7 non-cancerous adjacent colon tissues were obtained by surgical operations. Our results suggest that aqueous soybean, mistletoe and red clover extracts may exhibit anti-tumoral activity by depleting hypoxanthine concentration in the cancer cells through XO activation, which may lead to lowered salvage pathway activity necessary for the cancer cells to proliferate in the cancerous colon tissue. Some foods like soybean, mistletoe and red clover may provide nutritional support to medical cancer therapy through inhibiting and/or activating key enzymes in cancer metabolism (Tab. 4, Ref. 33).
Keywords: gastric cancer, colon cancer, soybean, mistletoe, red clover, adenosine deaminase, xanthine oxidase.
Year: 2014, Volume: 115, Issue: 6 Page From: 367, Page To: 371
doi:10.4149/BLL_2014_072


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