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Neoplasma Vol.61, No.5, p.533-540, 2014 |
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Title: Far upstream element-binding protein 1(FUBP1) expression differs between human colorectal cancer and non-cancerous tissue | ||
Author: M. Y. JIA, Y. J. WANG | ||
Abstract: Presented study aimed to detect the expression of far upstream element-binding protein 1 (FUBP1) in clinical samples of colorectal carcinoma (CRC) and explore the correlations of their expression with the clinicopathological characteristics of CRC. The positive rate of FUBP1 was detected through histochemistry in colorectal carcinomas (82.3%) which was higher than that in colorectal adenomas (46.7%) and surrounding normal tissues (20.5%). The relative amount of FUBP1 mRNA by qPCR method in colorectal carcinoma tissues (0.2703±0.1118) was higher than that of surrounding normal tissues (0.1898±0.0635; P<0.05). The Western blot showed that FUBP1 was mainly expressed in colorectal carcinoma tissues (0.6499±0.1473),which barely expressed in adenoma tissues (0.3756±0.1377; P<0.05) and surrounding normal tissues (0.1675±0.0613; P < 0.05).
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Keywords: FUBP1, colorectal carcinoma, immunohistochemistry, qPCR, Western blot | ||
Published online: 16-Jul-2014 | ||
Year: 2014, Volume: 61, Issue: 5 | Page From: 533, Page To: 540 | |
doi:10.4149/neo_2014_065 |
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