Home Neoplasma 2014 Neoplasma Vol.61, No.5, p.607-616, 2014

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Neoplasma Vol.61, No.5, p.607-616, 2014

Title: Vitamin D receptor FokI, BsmI, ApaI, and TaqI polymorphisms and the susceptibility to breast cancer: a meta-analysis
Author: Y. H. LEE, G. G. SONG


The goal of this study is to examine whether vitamin D receptor (VDR) polymorphisms are associated with the susceptibility to breast cancer.
Meta-analysis was employed to investigate the association between the VDR FokI, BsmI, ApaI, and TaqI polymorphisms and the incidence of breast cancer.
A total of 32 comparative studies were evaluated in this meta-analysis, which included 17,067 patients and 20,843 controls.

Meta-analysis of the VDR FokI polymorphism indicated an association between the incidence of breast cancer and the ff genotype in Europeans (OR = 1.126, 95% CI = 1.026–1.243, p = 0.019).

Furthermore, an association between the incidence of breast cancer and the VDR FokI polymorphism was found in the Europeans using the allele contrast, as well as the homozygote contrast.

However, the meta-analysis indicated no association between breast cancer and the BsmI polymorphism in all study subjects, including the Europeans (OR for the B allele = 0.996, 95% CI = 0.964–1.097, p = 0.930, 1.026, 95% CI = 0.929–1.134, p = 0.610).

Moreover, breast cancer incidence was not associated with the ApaI and Taq polymorphisms (OR for the A allele = 0.908, 95% CI = 0.763–1.041, p = 0.167, OR for the T allele = 0.972, 95% CI = 0.929–1.017, p = 0.221).

This meta-analysis suggests that the VDR FokI polymorphism is associated with susceptibility to breast cancer in the European population.

Keywords: breast cancer, vitamin D receptor, polymorphism, meta-analysis
Published online: 17-Jul-2014
Year: 2014, Volume: 61, Issue: 5 Page From: 607, Page To: 616

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