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Bratislava Medical Journal Vol.115, No.7, p.400-404, 2014 |
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Title: Investigation of the effects of propofol and vitamin C administration on erythrocyte deformability in rats with streptozotocin-induced | ||
Author: F. M. Comu, L. Ozturk, M. Alkan, K. Pampal, M. Arslan, B. Isik, M. S. Atac, D. Yilmaz | ||
Abstract: Purpose: In the current study we aim to investigate the effects of vitamin C and profol on red blood cell deformability in diabetic rats In group DP (n = 7) 150 mg.kg-1 of propofol was injected intraperitoneally. In group DP-vit C (n = 7) rats 100 mg/kg of vitamin C (Ascorbic acid, Redoxon® 1000 mg/5 mL - Roche) were applied one hour before administrating 150 mg.kg-1 of propofol, while rats in control group (n = 7), and diabetic control group (n = 7) received intraperitoneally physiological saline. Deformability measurements were achieved by using erythrocyte suspensions with hematocrit level of 5 % in PBS buffer. Erythrocyte deformability was significantly higher in diabetic control group than in control and vitamin C plus propofol groups (p = 0.00, p = 0.025, respectively). Erythrocyte deformability indexes were found similar in control group and vitamin C plus propofol group (p = 0.949). Relative resistance was increased in diabetic rat model. |
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Keywords: erythrocyte deformability, propofol experimental diabet, vitamin C, rat. | ||
Year: 2014, Volume: 115, Issue: 7 | Page From: 400, Page To: 404 | |
doi:10.4149/BLL_2014_0079 |
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