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Bratislava Medical Journal Vol.115, No.7, p.422-426, 2014 |
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Title: The protective effects of dexmedetomidine on liver injury- -induced myocardial ischemia reperfusion | ||
Author: D. Erer, A. Ozer, M. Arslan, G. L. Oktar, E. Iriz, C. Elmas, M. H. Zor, T. Tatar, G. Goktas | ||
Abstract: Purpose: The aim of this study was to evaluate the effect of dexmedetomidine (100 µg/kg-ip) on liver injury-induced myocardial ischemia and reperfusion (IR) in rats. Twenty-four Wistar Albino rats were separated into four groups. There were four experimental groups (Group C (Control; n = 6), Group IR (ischemia–reperfusion, n = 6), Group D (Dexmedetomidine; n = 6) that underwent left thoracotomy and received ip dexmedetomidine without IR administered via 100 µg/kg ip route 30 minutes before ligating the left coronary artery, and Group IR-D (IR-Dexmedetomidine; n = 6). A small plastic snare was threaded through the ligature and placed in contact with the heart. To produce IR, a branch of the left coronary artery was occluded for 30 min followed by two hours of reperfusion. However, after the above procedure, the coronary artery was not occluded or reperfused in the control rats. At the end of the study, liver tissue was obtained for histochemical and immunohistochemical determination. |
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Keywords: dexmedetomidine, myocardial ischemia reperfusion, remote organ, liver injury, i-NOS, rat | ||
Year: 2014, Volume: 115, Issue: 7 | Page From: 422, Page To: 426 | |
doi:10.4149/BLL_2014_083 |
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