Home Bratislava Medical Journal 2014 Bratislava Medical Journal Vol.115, No.8, p.502-507, 2014

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.115, No.8, p.502-507, 2014

Title: Exendin-4 effects on islet volume and number in the mouse pancreas
Author: L. Khorsandi, F. Nejad-Dehbashi


The aim of this study was to evaluate Exendin-4 (EX-4) effect on islet volume and number in the mouse pancreas.Thirty-two healthy adult male NMRI mice were randomly divided into control and experimental groups. EX-4 was injected intraperitoneally (i. p.) at the doses of 0.25 (E1 group), 0.5 (E2 group), and 1 μg/kg (E3 group), twice a day for seven consecutive days. One day after the final injection, the mice were sacrificed, and pancreas from each animal was dissected out, weighed, and fixed in 10 % formalin for measurement of pancreas, and islet volume and islet number by stereological assessments.

There was a significant increase in the weight of pancreases in E3 groups.

Islet and pancreas volumes in E1 and E2 groups were not changed compared to control group. E3 group showed a significant increase in islet and pancreas volume (p < 0.05).

There were no significant changes in the total number of islets in three experimental groups. The results revealed that EX-4 increased pancreas and islet volume in non-diabetic mice. The increased total islet mass is probably caused by islet hypertrophy without the formation of additional islets (Fig. 5, Ref. 35).

Keywords: exendin-4, pancreas, islet hypertrophy, stereology, mice.
Year: 2014, Volume: 115, Issue: 8 Page From: 502, Page To: 507

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