Home General Physiology and Biophysics 2014 General Physiology and Biophysics Vol.33, No.4, p.403–410, 2014

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.33, No.4, p.403–410, 2014

Title: Ionizing radiation as preconditioning against transient cerebral ischemia in rats
Author: Natália Kokošová, Viera Danielisová, Beňadik Šmajda, Jozef Burda

Abstract: Induction of ischemic tolerance (IT), the ability of an organism to survive an otherwise lethal ischemia, is the most effective known approach to preventing postischemic damage. IT can be induced by exposing animals to a broad range of stimuli. In this study we tried to induce IT of brain neurons using ionizing radiation (IR). A preconditioning (pre-C) dose of 10, 20, 30 or 50 Gy of gamma rays was used 2 days before an 8 min ischemia in adult male rats. Ischemia alone caused the degeneration of almost one half of neurons in CA1 region of hippocampus. However, a significant decrease of the number of degenerating neurons was observed after higher doses of radiation (30 and 50 Gy). Moreover, ischemia significantly impaired the spatial memory of rats as tested in Morris’s water maze. In rats with a 50 Gy pre-C dose, the latency times were reduced to values close to the control level. Our study is the first to reveal that IR applied in sufficient doses can induce IT and thus allow pyramidal CA1 neurons to survive ischemia. In addition, we show that the beneficial effect of IR pre-C is proportional to the radiation dose.

Keywords: Ischemia — Preconditioning — Ionizing radiation — Hippocampus — Morris’s water maze
Year: 2014, Volume: 33, Issue: 4 Page From: 403, Page To: 410

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