Home HOME General Physiology and Biophysics 2014 General Physiology and Biophysics Vol.33, No.4, p.443–452, 2014

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.33, No.4, p.443–452, 2014

Title: Sodium tungstate alleviates biomechanical properties of diabetic rat femur via modulation of oxidative stress
Author: Baris O. Donmez, Nihal Ozturk, Mehmet Sarikanat, Nurettin Oguz, Ramazan Sari, Semir Ozdemir

Abstract: Diabetes mellitus leads to bone disorders such as osteopenia and osteoporosis that can increase fracture risk. On the other hand, sodium tungstate is an inorganic compound which exerts anti-diabetic activity in experimental studies due to its suggested insulin-mimetic or antioxidant activity. Therefore this study was designed to investigate the effect of tungstate on bone quality in diabetic rat femurs. The rats were divided into four groups: Control (C), tungstate-treated control (C+Tung), diabetes (STZ-D) and tungstate-treated diabetes (STZ-D+Tung). Diabetes mellitus was induced by single injection of streptozotocin (50 mg/kg). The treated rats received 150 mg/kg/day of sodium tungstate for 12 weeks. Sodium tungstate achieved a little (17%) but significant reduction on blood glucose levels, while it didn’t recover the reduced body weights of diabetic rats. In addition, impaired bone mechanical quality was reversed, despite the unchanged mineral density. Sodium tungstate administration significantly lowered the 2-thiobarbituric acid reactive substances and restored the activity of tissue antioxidant enzymes such as glutathione peroxidase, catalase and superoxide dismutase in diabetic rats. On the other hand, glutathione levels didn’t change in either case. These findings indicate that tungstate can improve the reduced mechanical quality of diabetic rat femurs due probably to reduction of reactive oxygen species and modulation of antioxidant enzymes as well as reduction in blood glucose levels.

Keywords: Diabetic osteopenia — Sodium tungstate — Oxidative stress — Antioxidants — Bone quality — Mechanical strength
Year: 2014, Volume: 33, Issue: 4 Page From: 443, Page To: 452

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