Home Acta Virologica 2014 Acta Virologica Vol.58, No.3 p.287-291, 2014

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.58, No.3 p.287-291, 2014

Title: Wild and attenuated vaccine RS-12 strains of mumps virus exhibit differences in amino acid sequences of their proteins
Author: B. ALIREZAIE, R. SHAHBAZI, S. S. SAFAVIEH, A. MOHAMMAD

Abstract: Attenuated mumps virus (MuV) RS-12 strain-based vaccine is one of several effective vaccines available in the prevention of mumps. Since previous studies have unveiled only about one-third of the attenuated vaccine RS-12 strain genome sequence, the rest of sequence and molecular basis for attenuation remained unsolved. Therefore, in this study, the full-length genome sequences of wild and attenuated RS-12 strains were determined and compared. The comparison revealed nucleotide substitutions at 9 positions leading to amino acid substitutions at 6 positions in P, V, I, M, and L proteins, while the remaining substitutions were silent. This result indicates that the observed mutations in P, V, I, M, and L proteins of MuV might be responsible for the attenuation of the RS-12 vaccine strain.

Keywords: mumps virus; vaccine; attenuation; mutation
Year: 2014, Volume: 58, Issue: 3 Page From: 287, Page To: 291
doi:10.4149/av_2014_03_287


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