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Bratislava Medical Journal Vol.115, No.9, p.573-578, 2014 |
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Title: Vitamin D status, bone metabolism and bone mass in patients with alcoholic liver cirrhosis | ||
Author: Z. Savic, D. Damjanov, N. Curic, B. Kovacev-Zavisic, L. Hadnadjev, J. Novakovic-Paro, S. Nikolic | ||
Abstract: Introduction: Osteoporosis is seen in some 12–50 % patients with liver cirrhosis. Detrimental effects of alcohol are exerted directly on the bone cells and indirectly on hormones. Vitamin D is involved in osteoblast differentiation, bone matrix synthesis and bone mineralization, as well as in its decomposition. Vitamin D deficiency has been reported in about 2/3 patients with liver cirrhosis.
Osteocalcin levels were below the lower limit of normal in 86.7 % patients. CrossLaps was increased in only 20 % patients, but a significant increase was noted in Child-Pugh C class patients. Osteoporosis was diagnosed in 20 % of patients, with no correlation with disease severity and vitamin D status. |
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Keywords: alcoholic liver cirrhosis, vitamin D, bone metabolism, bone mass. | ||
Year: 2014, Volume: 115, Issue: 9 | Page From: 573, Page To: 578 | |
doi:10.4149/BLL_2014_111 |
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