Home HOME Neoplasma 2015 Neoplasma Vol.62, No.1, p.1-15, 2015

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.62, No.1, p.1-15, 2015

Title: The contribution of TGF-β in Epithelial–Mesenchymal Transition (EMT): Down-regulation of E-cadherin via snail
Author: H. YU, Y. SHEN, J. HONG, Q. XIA, F. ZHOU, X. LIU

Abstract: TGF-β plays a central role in epithelial–mesenchymal transition (EMT), which is a highly conserved and reversible process that governs tumor development, invasion and metastasis. Through this transition, the epithelial cell acquires a migratory behavior which allows it to move away from the cell community and to integrate into the surrounding tissue. The cells lost epithelial phenotypes including the change of cell polarity and the loss of specialized cell-cell contacts, which related with the shortage of E-cadherin directly. The increasing reports indicated that TGF-β down-regulated the expression of E-cadherin through snail signaling pathway, which played an important role in the development of EMT. In this review, we summarized the contribution of TGF-β in EMT and discussed the molecular mechanism of snail signaling participating in the regulation of E-cadherin triggered by TGF-β.

Keywords: TGF-β, Epithelial-mesenchymal-transition (EMT), snail family, E-cadherin
Published online: 17-Oct-2014
Year: 2015, Volume: 62, Issue: 1 Page From: 1, Page To: 15

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