Home HOME Neoplasma 2015 Neoplasma Vol.62, No.1, p.16-26, 2015

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.62, No.1, p.16-26, 2015

Title: Cathepsin S as a cancer target
Author: L. ZHANG, H. WANG, J. XU

Abstract: Cathepsin S is a lysosomal enzyme that belongs to the papain family of cysteine proteases. Multiple studies indicate that cathepsin S acts not only as a crucial role in antigen presentation but also as an important protagonist of cancers. Cathepsin S has been shown to participate in dissolution and remodelling of connective tissue and basement membranes, resulting in the process of tumor growth, invasion, metastasis and angiogenesis. Therefore, cathepsin S has been suggested as a potential therapeutic target in cancer therapy. In the present study, we review the rapidly advancing field of cathepsin S in cancer therapy, highlighting the specific roles of cathepsin S in cancer.

Keywords: Cathepsin S, cancer, combined chemotherapy, inhibitors
Published online: 17-Oct-2014
Year: 2015, Volume: 62, Issue: 1 Page From: 16, Page To: 26

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