Neoplasma Vol.62, No.1, p.16-26, 2015
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| Title: Cathepsin S as a cancer target |
| Author: L. ZHANG, H. WANG, J. XU |
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Abstract: Cathepsin S is a lysosomal enzyme that belongs to the papain family of cysteine proteases. Multiple studies indicate that cathepsin S acts not only as a crucial role in antigen presentation but also as an important protagonist of cancers. Cathepsin S has been shown to participate in dissolution and remodelling of connective tissue and basement membranes, resulting in the process of tumor growth, invasion, metastasis and angiogenesis. Therefore, cathepsin S has been suggested as a potential therapeutic target in cancer therapy. In the present study, we review the rapidly advancing field of cathepsin S in cancer therapy, highlighting the specific roles of cathepsin S in cancer.
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| Keywords: Cathepsin S, cancer, combined chemotherapy, inhibitors |
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Published online: 17-Oct-2014
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| Year: 2015, Volume: 62, Issue: 1 |
Page From: 16, Page To: 26 |
doi:10.4149/neo_2015_003
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