Home HOME Neoplasma 2015 Neoplasma Vol.62, No.1, p.108-113, 2015

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.62, No.1, p.108-113, 2015

Title: Associations between the Expression of micro-RNA 214 and clinicopathologic parameters of glioma
Author: W. WANG, H. YAN, F. TIAN, Y. SU, J. XU, C. DOU

Abstract: It have been reported that miR-214 reduction facilitates UBC9 expression and is involved in the regulation of glioma cell proliferation. However, the specific role of miR-214 in glioma remains unknown. Thus, we investigated the relationship between expression level of miR-214 and clinico- pathological features and prognosis in patients with glioma in a follow-up of 5years. We used Chi-square tests for the categorical data and Mann–Whitney tests for continuous data. Survival time was calculated from the date of glioma diagnosis to the date of death or last follow-up. Survival analysis was estimated using the Kaplan–Meier method, log-rank test, and Cox-proportional hazards regression model. In the present study, we confirmed that the expression level of miR-214 was increased in glioma tissues compared with the non-neoplastic brain tissues. Next, the Kaplan-Meier analysis revealed that glioma patients with high miR-214 expression tend to have poorer overall survival. In addition, the multivariate analysis clearly demonstrated that high miR-214 expression was a statistically significant risk factor affecting overall survival in glioma patients, suggesting that miR-214 upregulation in gliomas is not only in a grade-dependent fashion, it is also a predictor of overall survival. Finally, subgroup analyses showed the significant prognostic value of miR-214 upregulation for glioma patients in those with low and high pathological grade. The results of this study showed that miR-214 was up-regulated in glioma tissues. The expression of miR-214 was associated with the pathological stages of glioma. The results of 5-years follow-up showed that the expression level of miR-214 is a significant prognostic factor for patients with glioma.

Keywords: miR-214, glioma, prognosis
Published online: 17-Oct-2014
Year: 2015, Volume: 62, Issue: 1 Page From: 108, Page To: 113

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