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Bratislava Medical Journal Vol.115, No.11, p.685-691, 2014 |
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Title: The inhibition effect of expressions of miR-221 and miR-222 on glioma and corresponding mechanism | ||
Author: Z. Zhang, B. Z. Cui, L. H. Wu, Q. L. Xu, Z. Wang, B. Yang | ||
Abstract: Purpose: This study was designed to investigate the expressions of genes miR-221 and miR-222 in glioma cells and elucidate the mechanism of the inhibition of expressions of miR-221 and miR-222 in glioma. Animal experiments showed that the glioma volume of AS-miR-221/222 treatment group was significantly different to that of the control group (p < 0.05). Furthermore, this difference gradually increased with time. It reached the maximum at the end of the observation period. In the U251 glioma specimens in AS-miR-221/222 treatment group, local glioma tissue developed necrosis foci. In addition, the nuclear size, color, heteromorphism, and new vessel number of these glioma tissues were decreased. |
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Keywords: miR-221, miR-222, glioma, inhibition, target gene. | ||
Year: 2014, Volume: 115, Issue: 11 | Page From: 685, Page To: 691 | |
doi:10.4149/BLL_2014_133 |
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