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Bratislava Medical Journal Vol.115, No.12, p.743-748, 2014 |
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Title: Morphine and nicotine addiction and withdrawal influence baroreflex sensitivity and blood pressure in two-kidney one clip hypertensive (2K1C) rats | ||
Author: M. Zeinivand, A. Shamsizadeh, A. A. Pourshanazari, G. Hassanshahi, M. Allatavakoli | ||
Abstract: Objective: This study aimed to investigate the effects of addiction to morphine and nicotine as well as their withdrawal on both baroreflex sensitivity and blood pressure in hypertensive rats. Results: Results demonstrated that BP and BRS were significantly lower in addicted to morphine and nicotine hypertensive rats compared to control (p < 0.05). Addiction withdrawal (in morphine and nicotine withdrawal rats) completely reversed BP and BRS to the pre-addiction levels (p < 0.05). Withdrawal in the only nicotine treated group lowered BP and BRS compared to group that had received morphine and nicotine together (p < 0.05).
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Keywords: hypertension, baroreflex sensitivity, morphine, nicotine. | ||
Year: 2014, Volume: 115, Issue: 12 | Page From: 743, Page To: 748 | |
doi:10.4149/BLL_2014_143 |
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