Home Bratislava Medical Journal 2014 Bratislava Medical Journal Vol.115, No.12, p.753-756, 2014

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345
 

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Bratislava Medical Journal Vol.115, No.12, p.753-756, 2014

Title: Role of the nitric oxide on rosuvastatin-induced relaxation of the calf cardiac vein during cooling
Author: M. S. Guresir, K. E. Nurullahoglu Atalik

Abstract: Objective: 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors including rosuvastatin do not only lower plasma cholesterol but also have non-cholesterol lowering effects on the vessel wall, which decrease cardiovascular complications. The aim of the present study was to evaluate the effect of cooling (to 28 °C) on the vasodilatation induced by rosuvastatin (10-9-3x10-4M) on serotonin-pre-contracted calf cardiac vein and the role of nitric oxide in these effects.
Material and methods: Ring preparations of veins obtained from calf hearts were suspended in organ baths containing 25 ml of Krebs-Henseleit solution, maintained at 37 °C and continuously gassed with 95% O2–5% CO2. After a resting period, preparations were contracted with serotonin (10-6 M) at 37 °C.
Results: Rosuvastatin produced concentration-dependent relaxation of calf cardiac vein precontracted with serotonin (10-6 M). During cooling, the pIC50 value, but not the maximal response, to rosuvastatin was significantly higher than at 37 °C. Cooling to 28 °C in the presence of NG-nitro-L-arginine methyl ester (L-NAME, 10-4 M) decreased the pIC50 values to rosuvastatin.
Conclusion: The results of the present study suggested that nitric oxide played an essential role in the cooling-induced changes of rosuvastatin in calf cardiac vein (Fig. 1, Ref. 23).

Keywords: cardiac vein, cooling, nitric oxide, rosuvastatin.
Year: 2014, Volume: 115, Issue: 12 Page From: 753, Page To: 756
doi:10.4149/BLL_2014_145


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