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Bratislava Medical Journal Vol.116, No.1, p.9-13, 2015 |
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Title: Collection of peripheral hematopoietic stem/progenitor cells | ||
Author: V. Rimajova Dihenescikova, M. Mistrik, J. Martinka, M. Zwiewka, I. Bizikova, A. Batorova | ||
Abstract: Objectives: Several variables possibly affecting collection of peripheral hematopoietic stem/progenitor cells (PBSC) were evaluated: type of apheresis machine (Amicus version 2.5, Baxter vs Cobe Spectra version 7.0, Terumo BCT), venous access (peripheral vein vs central venous catheter, i.g. CVC), and apheresis regimen (standard vs large volume leukapheresis, i.g. SVL vs LVL) with the objective to increase collection efficacy at the site. Results: With Cobe Spectra apheresis machine it was possible to process larger blood volumes per procedure with higher CD34+ cell collection efficiency (p = 0.0229) and lower RBC contamination of the harvest than with Amicus (p = 0.0116). On the other hand, Amicus helped to limit PLT contamination of the harvest (p < 0.0001), thus minimizing post-procedural decrease in patient´s PLT count. The highest detected advantage of CVC usage was higher flow rate of procedure, thus processing larger blood volumes per unit of time. Interesting finding was the tendency to lower harvest PLT contamination (p = 0.054). When LVL was performed, significantly higher HSCs yields were collected, even in “poor mobilizers” when the pre-run parameters were low. |
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Keywords: peripheral hematopoietic stem/progenitor cells, apheresis collection, central venous catheter. | ||
Year: 2015, Volume: 116, Issue: 1 | Page From: 9, Page To: 13 | |
doi:10.4149/BLL_2015_002 |
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