Home Bratislava Medical Journal 2015 Bratislava Medical Journal Vol.116, No.1, p.30-34, 2015

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.116, No.1, p.30-34, 2015

Title: Histopathological evaluation of potential impact of β-tricalcium phosphate (HA+ β-TCP) granules on healing of segmental femur bone defect
Author: H. Eftekhari, M. R. Farahpour, S. M. Rabiee

Abstract: Histopathological evaluation of β-tricalcium phosphate (HA+ β-TCP) granules demonstrated that it has properties to heal segmental femur bone defect in rat. In this study, 27 male white rats were examined. Rats were divided into tree groups. Surgical procedures were done after IP administration of ketamine 5 % and xylazine HCL 2 %. Then an approximately 5-mm long, 3-mm deep and 2-mm wide bone defect was created in the femur of one of the hind limbs using a No. 0.14 round bur. After inducing the surgical wound, all rats were colored and randomly divided into three experimental groups of nine animals each: Group 1 received medical pure β-tricalcium phosphate granules, group 2 received hydroxyapatite and third group was a control group with no treatment.
Histopathological evaluation was performed on days 15, 30 and 45 after surgery. On day 45 after surgery, the quantity of newly formed lamellar bone in the healing site in β-TCP group was better than onward compared to HA and control groups.
In conclusion, β-tri calcium phosphate (β-TCP) granules exhibited a reproducible bone-healing potential (Fig. 10, Ref. 28).

Keywords: bone healing, β-tricalcium phosphate (β-TCP), hydroxyapatite (HA), histopathological evaluation, rats.
Year: 2015, Volume: 116, Issue: 1 Page From: 30, Page To: 34

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