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Neoplasma Vol.62, No.2, p.259-268, 2015 |
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Title: Predictive factors for the presence of tumor cells in bone marrow and peripheral blood in breast cancer patients | ||
Author: M. Cabinakova, V. Mikulova, K. Malickova, D. Vrana, D. Pavlista, L. Petruzelka, T. Zima, P. Tesarova | ||
Abstract: Simultaneous detection of disseminated tumor cells (DTCs) and circulating tumor cells (CTCs) was shown to be associated with an especially poor prognosis and increased incidence of disease-related deaths in non-metastatic breast cancer patients. We analyzed the occurance of DTCs and CTCs in patients with primary breast cancer and evaluated the correlation of their presence with other prognostic markers and investigated the changes in DTCs/CTCs number at different time points during treatment. For CTC positivity, no such relationship was proven. DTCs have shown significantly higher prevalence in ER/PR-negative females and in HER2-positive cases. CTCs were equally prevalent in patients with the presence and absence of standard prognostic and predictive markers such as ER, PR and HER2. We found no correlation between CTCs and DTCs findings (r = -0.097, p = 0.504). We used DTCs/CTCs analysis for therapy monitoring in a small group of 29 patients, who underwent neoadjuvant chemotherapy (NACT). We find out no significant correlation between DTCs/CTCs detection and the primary tumor response to NACT. A pathologic complete response (pCR) was achieved by 31% (9/29) of the patients in our study, however, no association was observed between pCR and the detection of DTCs after NACT. |
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Keywords: breast cancer, disseminated tumor cells, circulating tumor cells, bone marrow aspiration, prognostic/predictive markers, therapy monitoring | ||
Published online: 14-Jan-2015 | ||
Year: 2015, Volume: 62, Issue: 2 | Page From: 259, Page To: 268 | |
doi:10.4149/neo_2015_031 |
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