Home CONTACT General Physiology and Biophysics 2015 General Physiology and Biophysics Vol.34, No.1, p.5–12, 2015

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.34, No.1, p.5–12, 2015

Title: Functional changes in piriform cortex pyramidal neurons in the chronic methamphetamine-treated rat
Author: Nobuaki Hori, Tomoko Kadota, Norio Akaike
Abstract: Chronic treatment of rats with methamphetamine (MAP) causes a range of functional changes to the central nervous system (CNS), including a toxicity that is widespread throughout the brain (Frost and Cadet 2000; Fasihpour et al. 2013). In this report, we examined the effect of chronic MAP treatment on pyramidal neurons of the rat piriform cortex, an area involved in sensory processing, associative learning and a model system for studies on synaptic plasticity. MAP treatment significantly depolarized the membrane potential and decreased neuronal input resistance. Furthermore, the voltage-dependence of both AMPA and NMDA responses was disturbed by chronic MAP treatment, and the extent of long-term potentiation (LTP) was decreased. Morphological changes of MAP-treated rat pyramidal neurons were observed as blebbing of the dendrite trees. The changes we observed represent detrimental effects on the function of piriform cortical neurons further illustrating deficits in synaptic plasticity extend beyond the hippocampus. These changes may contribute to behavioural deficits in chronic MAP-treated animals.
Keywords: Methamphetamine — Rat piriform cortex — AMPA — NMDA — LTP
Year: 2015, Volume: 34, Issue: 1 Page From: 5, Page To: 12
doi:10.4149/gpb_2014024


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