Home General Physiology and Biophysics 2015 General Physiology and Biophysics Vol.34, No.1, p.51–64, 2015

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.34, No.1, p.51–64, 2015

Title: Protection or cytotoxicity mediated by a novel quinonoid-polyphenol compound?
Author: Ivana Milackova, Lucia Rackova, Magdalena Majekova, Natasa Mrvova,  Milan Stefek

Abstract: Many natural and synthetic quinones and naphthoquinones possess a variety of beneficial pharmacological properties. In plants, the cytotoxic properties of quinones serve in their defensive roles against invading bacteria, fungi and parasites. In this regard many quinones as well as polyphenols, exerting generally toxicity at high dosages, are able to induce favorable hormetic responses at a low dosage. The novel chloronaphthoquinone derivative of quercetin (CHNQ) showed a profound cytotoxicity followed by enhancement of intracellular generation of oxidants in human neonatal B-HNF-3 fibroblasts. Its synthetic precursors, quercetin and 2-chloro-3-hydroxy-[1,4]naphthoquinone, failed to induce these effects, and paradoxically, only CHNQ at a low concetration provided partial protection of the cells against oxidative challenge. Thus, the novel quinonoid-polyphenol CHNQ might have a merit in the search for new prospective agents in prevention and management of ageing and ageing-related pathologies.

Keywords: Hormesis — Quinones — CHNQ — Oxidative stress
Year: 2015, Volume: 34, Issue: 1 Page From: 51, Page To: 64
doi:10.4149/gpb_2014028


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