Home General Physiology and Biophysics 2015 General Physiology and Biophysics Vol.34, No.1, p.95–99, 2015

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.34, No.1, p.95–99, 2015

Title: Intestinal ischemia-reperfusion injury mediates expression of inflammatory cytokines in rats
Author: Kristína Gregová, Štefan Číkoš, Miroslava Bilecová-Rabajdová, Peter Urban, Ján Varga, Štefan Feterik, Jarmila Veselá

Abstract: The small intestine is an organ with very well developed immunological activity, responsible for synthesis of specific inflammatory mediators that participate in causing the systemic inflammation that can occur after ischemia-reperfusion injury. The aim of our work was to study mRNA expression and protein concentration of inflammatory cytokines IL-10 and TNFα in the jejunal wall after intestinal ischemia-reperfusion injury (IRI). Cytokine concentration levels confirmed the direct effect of IRI on the inflammation process. The results refer to the changes in balance between pro-inflammatory and anti-inflammatory mediators and indicate that the predominant disturbance of homeostasis after intestinal IRI is present after 1 hour of reperfusion.

Keywords: Intestinal ischemia-reperfusion — Cytokines — Rat
Year: 2015, Volume: 34, Issue: 1 Page From: 95, Page To: 99

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